CBD and Neuropathic Pain
Cannabidiol (CBD) has been studied as a solution for neuropathic pain, a complex, chronic state of pain that is usually accompanied by a tissue injury. With neuropathic pain, nerve fibers may be damaged and send incorrect signals to other pain centers, creating an onset of pain that can be difficult to ease. CBD makes a good candidate due to its anti-inflammatory and pain inhibiting (also known as antinociceptive) behavior. Chronic and neuropathic pain can be extremely difficult to manage, and solutions often vary from study to study. Many studies have been conducted in order to determine how effective CBD is in easing chronic or neuropathic pain that comes with a variety of different illnesses or ailments.
CBD has been studied in correlation with and been found beneficial in conditions such as diabetes, rheumatoid arthritis, cancer, epilepsy, antibiotic-resistant infections, alcoholism, PSTD and neurological disorders.
Some findings include:
- In a study aimed at reducing the painful side effects of Paclitaxel (also known as PAC - a drug used to treat cancers), which is associated with chemotherapy-induced neuropathic pain (CIPN). CBD was found to prevent PAC-induced mechanical and thermal sensitivity.
- CBD is protective against PAC-induced neurotixicity.
- Treatment with CBD during PAC chemotherapy may be safe and effective in the prevention or attenuation of CIPN.
- Cannabinoids including a cannabidiol/THC buccal spray are effective in treating neuropathic pain in multiple sclerosis.
- Cannabidiol has substantial anti-inflammatory and immunomodulatory effects that act as an effective therapeutic agent for chronic inflammatory and neuropathic pain.
- A study that investigated its therapeutic potential on neuropathic and inflammatory pain showed daily oral treatment with cannabidiol, or intraplantar injection, reduced hyperalgesia (heightened sensitivity to pain) to thermal and mechanical stimuli. The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.
- Neuropathic orofacial pain (NOP), such as burning mouth syndrome (BMS), persistent idiopathic facial pain (PIFP), trigeminal neuralgia (TN) and postherpetic neuralgia (PHN) still have unclear pathophysiology which makes treatment difficult. The analgesia (inability to feel pain) associated with cannabinoid system has made cannabinoid compounds such as CBD effective in treating this form of neuropathic pain associated with NOP.
- Shannon Kaszuba